Choline Supplementation Inhibits Diethanolamine-Induced Morphological Transformation in Syrian Hamster Embryo Cells: Evidence for a Carcinogenic Mechanism
نویسندگان
چکیده
منابع مشابه
Morphological transformation, DNA damage, and chromosomal aberrations induced by a direct DNA perturbation of synchronized Syrian hamster embryo cells.
number of photochemical lesions in BrdUrd-substituted DNA than in nonsubstituted DNA. The major photoproduct is uracil, which is formed by the dissociation of bromouracil in the radical formation, and these radicals may extract an electron from the furanose backbone. This ultimately leads to a break in the DNA, particularly when it is subjected to alkaline conditions (22,35). Several studies (3...
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The cytogenetic effects of chrysotile asbestos on Syrian hamster embryo cells in vitro were investigated at doses which induced morphological and neoplastic transformation but which failed to induce measurable gene mutations in the cells at two genetic loci. Chrysotile asbestos treatment of the cells significantly induced chromosome changes in a dose-dependent manner. Up to 50% of the cells had...
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A mammalian cell culture system using normal, diploid Syrian hamster embryo fibroblasts was used as a model to study the ability of diethylstilbestrol (DES) and related compounds to induce neoplastic transformation. Like benzo(a)pyrene, a known chemical carcinogen, DES (0.01 to 10 /ig/ml) induces morphological transformation of Syrian hamster embryo fibro blasts in vitro; the transformed coloni...
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Cobalt sulfate hydrate, gallium arsenide, molybdenum trioxide, vanadium pentoxide, and nickel sulfate heptahydrate were tested in the Syrian hamster embryo (SHE) assay in order to increase the SHE assay database for heavy metals. All five compounds produced significant morphological transformation at one or more doses in a dose-responsive manner. Cobalt sulfate hydrate, gallium arsenide, molybd...
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when the concentration of the exogenous metabolic system was five to ten fold that used generally. Acid-treated oils were not mutagenic to S. typhimurium in the presence of an exogenous metabolic system; solvent-refined oils were reported to be mutagenic in the presence of an exogenous metabolic system. Hydrotreated oil was reported to be mutagenic to S. typhimurium in the presence of an exogen...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2000
ISSN: 1096-0929
DOI: 10.1093/toxsci/55.2.303